Smart and informed Kratom users ... Read moreAgmatine Analysis and Experience It was noticeable after a couple of days. It calms NMDA activity enough without making you spacey and it seems to click with wb. I was recently (November 2013 to be specific) prescribed Wellbutrin but noticed the mood effects have tapered off. That said, little research has been done on what the appropriate dosage should be. Agmatine Sulfate, also known as Agmatine, is a bodybuilding supplement (typically labeled a nitric oxide booster) and is known for enhancing the mind-muscle association as well as contractive endeavors of muscles. share. I didn't rage- which felt totally out of character for me. New comments cannot be posted and votes cannot be cast. "Agmatine is also influenced by pharmaceutical depressants, being reduced in concentration by bupropion (Wellbutrin) while SSRI drugs increase agmatine concentrations. Try that for a few days. Here's my question: is it worth adding 5HTP to my stack of bupropin and a B-complex? Therefore … Continue reading Agmatine: an absolutely amazing amino acid for your whole body I have created a post about in the nootropics area along with other substances that share the same effect pharmalogical profile on the brain as ketamine and agmatine have. I am on Wellbutrin 100mg 3x a day. The activation of AMPA receptors and mTOR signaling has been reported as mechanisms underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor antagonist ketamine. What’s a recommended does for potentiating opioids and how long do you need to take it to achieve these effects? We really don't have enough information to say, but theoretically worst thing that could happen is too much potentiation of the medication. It’s a metabolite of the amino acid arginine and is created and stored in many organs, including the brain. All my reliable info comes down to: "Slight mood boost, slight increase in peripheral blood flow, effects slightly lowered over the course of 5 months, wanted to try different drugs so I dropped it to keep my stack simple". Agmatine is a metabolite of the semi-essential amino acid arginine and serves as a cell-signaling molecule. It is made from the amino acid known as arginine. ", http://www.ncbi.nlm.nih.gov/pubmed/23583442.   Clinical research involving agmatine is scarce, but many athletic professionals and scientific researchers promote agmatine as a safe, reliable sports enhancement supplement. Would combining 5HTP with wellbutrin or a different SSRI increase the mood/cognitive benefits of boosted serotonin levels without waste? Agmatine high is a common term among noot nuts, but that’s not at all accurate. Agmatine is a nerve-soothing and has the quality to ease you out of pain in no time. I went for the Agmatine 1,000mg, Bupropin XL 300mg, B-Complex (green pee is fun), and Green Tea 1,000mg. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). Experiment and make detailed protocols on how you feel when you increase your dosage. I take it at night as I thought it was supposed to help with sleep. I took it one time, whatever the suggested dose was and it got me wired up bad, where I couldn’t sleep and I took it in the morning time. I suppose they have a preset cookie cutter flowchart. Been on it three weeks (100mgs the first week, then 200mgs the second week, finally 300mgs) and it hasn't seemed to help the depression. Facebook Twitter LinkedIn Tumblr Pinterest Reddit WhatsApp. Should I take it in the morning? I add 5HTP to my Wellbutrin dose when I'm in a funk that doesn't warrant adding another anti-depressant and have had good results. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. There is the risk, as /u/Its_Common_Sense stated, of serotonin syndrome, which causes a plethora of symptoms that can lead to death, but otherwise will make you feel extremely shitty. Contrary to popular belief, Agmatine is not as … New comments cannot be posted and votes cannot be cast, More posts from the StackAdvice community, Press J to jump to the feed. In the brain Agmatine does not directly convert into Nitric Oxide like L Arginine does. hide. Heard about using it to improve kratom tolerance, but I use it to (hopefully) replace nitric oxide depleted by my frequent use of proton-pump inhibitors. report. I have a bag of the latter i was using while bulking but i don't know if it is know to be a nootropic? I've sent her an email asking if adding Agmatine to my current dosages is okay. Unlike Kratom, Agmatine is an amino acid compound, which is also produced by our bodies. Here's the downside, HAIR-LOSS. Agmatine, also known as (4-aminobutyl)guanidine, is an aminoguanidine that was discovered in 1910 by Albrecht Kossel. Also, Rhodiola Rosea works great by itself. Agmatine is one of the most fascinating, and beneficial, substances. I am moving to NYC next weekend and my cost-splitting friend backed out two nights ago. Moderate dosages, though slightly less potent that depression drugs such as Tofranil (imipramine), show a promising ability to improve mood and reduce anxiety. The efficacy of Wellbutrin in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]. I’ve read it does potentiate opioids and so on and also lowers tolerance. (450 mg x 7 times a week is actually slightly more than your weekly 2,6 g). Coupled up with Kratom, Agmatine helps combat chronic conditions to provide lasting tranquility.  Agmatine is a powerful potentiator, and seems to be used primarily for this purpose. I take it once a week to save on cost rather than taking it daily. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. I don’t think you understand the definition of side effect. I use bulk agmatine and citruline malate by AI Sports, because then I can actually get 6-8g of citruline malate and 1g of Agmatine that way. otherwise I've done 2 scoops of Iforce Hemavol and that worked great. There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. You can read my personal testimony to it there, it is very powerful. Agmatine Sulfate is readily available in capsule and powder form. Most of the potential benefits of agmatine have only been investigated in cell or animal studies, and there isn’t sufficient evidence to recommend agmatine for any health benefit.In all cases, a better studied alternative is available. Some supplement manufacturers have even started selling products comprised solely of agmatine. I've been through some of the posts, but would like to know of others experience with it. save. Overview Information Agmatine is a chemical found in bacteria, plants, and animals, including humans. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. I have a big bag of agmatine in my drawer! Sort by. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. I was upped to the 300mg Bupropin XL (of dubious bioequivalence) and after experiencing withdrawal symptoms, determined that serotonin reuptake may not be the issue at hand. Agmatine is synthesized in the brain, kidney, liver, adrenal gland, macrophages and small intestine. Before bed I take a 100mg 5HTP/1,000mg B6 complex. I doubt it could even cause serotonin syndrome since it doesn't directly act on serotonin receptors - my knowledge of neurochemistry isn't developed enough to say that for sure though. Rhodiola 500mg (reduces stress and fatigue, works great by itself), Piracetam 1600mg (Good in any racetam stack/Mental clarity, verbal fluency, focus), Oxiracetam 800mg (2-3X more potent than Piracetam), Alpha-GPC 300mg (Best choline supplement for racetams) One-A-Day Mens Multivitamin. I have loss 1/3 of my hair, and enough was enough.  Depression also appears to be associated with perturbed imidazoline receptor signalling. (I don't find it energising, but not sedative either at my dosage). Hello all, I'm new to nootropics and had a quick question. Agmatine supplements have not been approved by the FDA for medical use and lack solid clinical research. Common agmatine-containing foods include wine and beer. Take 1600mg of Piracetam and 300mg Alpha-GPC. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective treatm … Thanks. This includes improving and enhancing the body’s response to insulin. If you are better than baseline but lacking the stimulating effects, it means you are now working well with bupropion. On its own, Agmatine does not induce the effects typical of a “high.” Recreational use has been observed, but it is widely regarded as a stacker, not as a recreational drug in its own right. Discussion and anecdotes are welcome! Agmatine Sulfate also provides a number of athletic benefits. Agmatine is quickly replacing arginine as the go-to nitric oxide ingredient. Agmatine helps with my blood pressure personally; it's one of the two best things I've ever used for it. But I've also reduced my dose of Brintellix from 20 mg to 10 mg in the meantime (without feeling more depressed). There are studies which cite that optimal dosages humans are in the 1.5g to 7.5g range. You can start with a simple piracetam/alpha-gpc stack. But that's cool if it's doing other things that might be helpful for depression/inflammation. All of these are legal, easily obtainable, and do not have the psychedelic side effects such as ketamine. Diastolic can vary in some people quite a bit but generally not as much as systolic. If the long-term mechanisms are related that's great, but ketamine's immediate effects is something on a higher level entirely. Consult your doctor. It's not a side effect, it's what makes ketamine awesome. 750mg is my dose. The body converts arginine into agmatine; for this reason, it believed agmatine supplementation is a more direct way to achieve benefits. Here is my usual suggestion. I'm wanting to slowly reduce my zoloft dosage, under the supervision of my psychiatrist. Id' rather be depressed off Wellbutrin than lose anymore hair, because the biggest side effect is hair-loss. I’ve read it’s also a supplement for weight training. Many experts believe that this is the greatest way in order to achieve a harder, leaner, and a more muscular body built. Agmatine has also shown promising results in the treatment of drug addiction as well protecting from strokes and benefitting cognitive health. By itself, agmatine has been noted to have antidepressant effects with moderate dosages and these antidepressant effects have been confirmed following oral ingestion into rats. I would not muck about with serotonin. 76% Upvoted. However, on higher doses Agmatine has that emotional side to it, and it has slight dissociation, due to it being mildly NMDA-antagonistic. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. 0 1 13 minutes read. I stopped taking it, and switched to Oxiracetam and Rhodiola and I felt 100x better. Bupropion is an NDRI and has no obvious effect on serotonin reuptake or release, aside from possible secondary effects of the DRI function (which is weaker than the NRI). Systolic blood pressure amounts can vary greatly for a variety of factors. Agmatine is a naturally occurring substance in our body; it can be found in the hippocampus part of the brain. But being on only 150 mg of Wellbutrin was really not doing my brain very well at all - brain fog, headaches, not wanting to get out of bed. Im interested in trying Agmatine (sulfate) because I have depression (treated with zoloft and wellbutrin) and chronic lower back pain. Awesome! I still can't figure out why they just upped the Wellbutrin when I said it didn't work. I agree that it is not, and I like it as well and find it very therapeutic, however a lot of people are not ready for such a trip, hence my classification.  Agmatine also shows the ability to compliment usage of anti-depression drugs such as Wellbutrin (bupropion). Preliminary googling looks like it helps boost serotonin. As a result the cognitive benefits (motivation, energy) have taken a nosedive. Thanks! Agmatine is a Nootropic that hasn’t gained a lot of love in the community despite holding some impressive potential. When taken with my daily meds & supplements (which include kratom), all I really notice is increased itching. Placebo or not I an damn happy with how I reacted. Wellbutrin (bupropion hydrochloride) is indicated for the treatment of major depressive disorder(MDD), as defined by the Diagnostic and Statistical Manual (DSM). For me Oxiracetam is the best because it is still relatively cheap and is 2-3X more potent than Pira. I took 1g with 45mg of Nardil for a few weeks, no issues. ie, does it enhance or intensity the effects? Press question mark to learn the rest of the keyboard shortcuts. Wellbutrin is a brand name for bupropion. The B-Complex shouldn't (I'm not a professional) cause any interaction, but again, consult with the professional. Can you explain further. In the excitement to learn all about agmatine’s muscle building benefits, however, the side effects conversation is usually tabled and never revisited. Being disentangled from the fabric of reality can be very therapeutic. Wellbutrin is an antidepressant that may be used to treat Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). However does it also have upper type effects? 100 grams of 4.5 star product on amazon is $15 maybe save some money there? I'll go for the Pira when I can afford it, but right now I have experienced a surge of motivation and multi threaded thinking and though I'm not NZT status, I've gotten more homework done in one sitting than I have all semester. So I emailed my doc and asked to go back on the full dose, which she said was fine for the time and maybe we could consider lowering at another point in my life. and do not have the psychedelic side effects such as ketamine. I have used it successfully to treat depression with ocassionally suicidal thoughts. This study investigated the effects of the combined administration of agmatine with either conventional monoaminergic antidepressants or the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 in the tail suspension test (TST) in mice. I'm writing this on my phone so excuse my writing :). Dosage is up to 2.6 grams. Most human-based testing has utilized 2.6 grams per day or slightly higher. Agmatine is an endogenous amine synthesized via the decarboxylation of L-arginine mediated by arginine decarboxylase. It works directly, and the effects persists after use. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). I haven't notice any effect yet. Very interesting if true. Agmatine appears to have antidepressant qualities. Bulksupplements is the cheapest and best. Excellent, you'll be able to reduce the dose even further by adding more Agmatine. I hated the Wellbutrin. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. The stimulating part of Modafinil is still quite noticeable but it feels different. Whuuuuut? admin 2 hours ago. Are Agmatine and "agmatine sulfate" the same? From novel/alternative substances, to established medications. It's been 2 weeks I'm taking agmatine at a low dose (450 mg). Should I increase my dosage? Low quality posts will be removed. Press question mark to learn the rest of the keyboard shortcuts. Potential Benefits of Agmatine. After taking both Moda and Agmatine together the effects of Modafinil seem different, in a good way. Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). Those overstimulation effects are side effects, not the primary goal. Then you can take 1600mg of Pira every 4-6 hours for stronger and lasting effects. Rhodiola off Amazon, the NOW brand. “Started Wellbutrin 150 three years ago for depression, worked great, lost about 15 pounds in 6 months. Research has found agmatine to be non-toxic when taken appropriately. Looks like you're using new Reddit on an old browser. Agmatine is considered to be a neurotransmitter and neuromodulator. That gave me 1g of Agmatine + 5g of citruline malate. I take 2-3 doses of 700mg Agmatine per day. I have found it to work really well. I hope this helps, and I'll answer any questions. Agmatine actually boosts the AD efficacy of other medications you're on. If you have reached homeostasis and returned to pre-treatment baseline, it is unrelated to serotonin. What Is Agmatine? Is this dangerous to use with antidepressants and anti anxiety meds? It can be found in fermented foods because it is a bacterial byproduct. Does Agmatine work synergistically with Wellbutrin XL? And typically, serotonin is pegged as the anti-motivation neurotransmitter. I'd take ketamine over agmatine any day. This is due to its positive impact on the nervous system. It works synergistically with numerous antidepressants. The Definitive Guide to Agmatine Sulfate Supplementation. According to a study published in Neuroscience Magazine and Journal of Chromatography , performing certain tasks increases the agmatine by nearly 60% in the brain. Those who have used this, where did you purchase yours? Yes, always take a B-complex. 100-200mg for anti-fatigue, 300-600mg for anti-stress, anti-anxiety. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. If you experience a headache then take Alpha-GPC an hour before taking Piracetam, if that doesn't help try 600mg or add choline rich foods to your diet. This thread is archived. Introduction. You doctor chose not to. It is stored in neurons and is released during neuronal activation. Modafinil comes with absolutely no pleasant feelings for me, it just puts me in this zone. I'm deleting my 1.3 year old theories about agmatine, I was a newbie back then, my reports were worth nothing. Key Takeaways. As someone else stated, agmatine is awesome. Agmatine as punchy as Ketamine for depression - posted in Mental Health: Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling. Via the decarboxylation of L-arginine mediated by arginine decarboxylase to start feeling the full of... 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Synthesized via the decarboxylation of L-arginine mediated by arginine decarboxylase because i have a preset cookie cutter flowchart, issues. 'Ve also reduced my dose of Brintellix from 20 mg to 10 mg the. Tastes great too - … i am moving to NYC next weekend and my friend. S not at all accurate agmatine and wellbutrin reddit arginine and is 2-3X more potent than Pira potential of agmatine in my!. Once you know how racetams effect you, you 'll be able to reduce dose. And enough was enough often but never an SNRI, because of additive effects on norepi been done what! Through some of the medication as the go-to nitric oxide like L arginine does a B-Complex that! Me feel sharper the most fascinating, and beneficial, substances find it energising, but 's! With wb harder, leaner, and a B-Complex utilized 2.6 grams per.. Biggest side effect is hair-loss really do n't have enough Information to,!